Biological applications of ionophores
WebJan 24, 2024 · DNA based ionophores can mediate efficient ion transport and are crucial to understand the biological role of their natural counterparts. Here authors engineer a telomeric DNA G-quadruplex based ... WebIonophores transport ions across biological membranes and have wide-ranging applications, but a platform for their rapid development does not exist. We report a platform for developing ionophores from metal-ion chelators, which are readily available with wide-ranging affinities and specificities, and structural data that can aid rational design.
Biological applications of ionophores
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WebMay 27, 2024 · Despite several ionophores revealing potential therapeutic applications as apoptosis inducers, ... In the context of transporting molecules of biological relevance, quite a few ionophores have been … WebPolyether ionophores are complex natural products capable of transporting cations across biological membranes. Many polyether ionophores possess potent antimicrobial activity and a few selected compounds have the ability to target aggressive cancer cells. Nevertheless, ionophore function is believed …
WebJan 15, 2000 · Monopodal and oligopodal Mg2+-selective ionophores were characterized by their selectivity coefficients (Separate Solution Method, SSM) in plasticized poly ... “Chemical Sensors and Biosensors for Medical and Biological Applications”, 1998, Wiley–VCH, Weinheim. M. Müller, M. Rouilly, B. Rusterholz, M. Maj-Zurawska, Z. Hu, … WebIonophores are a class of compounds that form complexes with specific ions and facilitate their transport across cell membranes. An ionophore typically has a hydrophilic pocket (or hole) that forms a binding site specific for a particular ion. The exterior surface of an ionophore is hydrophobic, allowing the complexed ion in its pocket to cross the …
WebThe structure and physical chemical properties are reviewed of various ionophores, small molecules which transport cations across biological membranes. The subclass of carboxylic ionophores has dramatic pharmacological properties, dilating the coronary arteries and increasing cardiac contractility, which make them especially interesting.
WebNov 1, 2024 · Copper ionophores alter the concentration, distribution, and reactivity of endogenous copper ions with consequent profound biological repercussions. The …
WebAnalogous ionophores have now been synthesized. Unique applications for these compounds are emerging, based either on their selective toxicity or ability to modify … list of animal moviesWebMay 27, 2024 · A comprehensive investigation of the structure-activity relationships, selectivity aspects and biological implications in terms of potential therapeutic applications of these ionophores will be … list of animal noisesWebThe control of ion transport and homeostasis is a critical function of living organisms. In this perspective, an overview of different synthetic systems capable of facilitating the transmembrane transport of ions along with the biological activity exerted by these compounds is presented. Examples of both cat list of animal petsIn chemistry, an ionophore (from Greek ion and -phore 'ion carrier') is a chemical species that reversibly binds ions. Many ionophores are lipid-soluble entities that transport ions across the cell membrane. Ionophores catalyze ion transport across hydrophobic membranes, such as liquid polymeric membranes (carrier-based ion selective electrodes) or lipid bilayers found in the living cells or synthetic vesicles (liposomes). Structurally, an ionophore contains a hydrophilic center … images of merritt pattersonWebAs it has turned out, medical and pharmaceutical applications of ionophores are limited, since the activity of ionophores is not restricted to microbial membranes. On the other … list of animal kingdomWebMar 4, 2024 · Cu ionophores include HQs that have a vast variety of biological applications. The most known compound of the HQ class is 7-iodo- 5-chloro-8-hydroxyquinoline (CQ) that was first used as an antibiotic and more recently has been studied for the repurposing in different diseases ranging from neurodegenerative … list of animal productsWebBiological applications of ionophores. Pressman BC. Annual Review of Biochemistry , 01 Jan 1976, 45: 501-530 DOI: 10.1146 ... Biological applications and evolutionary origins of ionophores. Pressman BC, deGuzman NT. Adv Exp Med Biol, 84:285-300, 01 Jan 1977 images of mermaid paintings