Cisplatin hearing loss data

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August undefined, 2024

WebJun 1, 2024 · Overall, for all cancers treated with cisplatin, the incidence of hearing loss is about 50%. But some specific cancers, especially children who have cancers in very early childhood—say, younger than 5 years old—tend to have a more severe cisplatin-induced hearing loss and at a higher incidence. WebJul 2, 2024 · Caffeine pre-treatment further reduced wave I and II amplitudes, suggesting worsening of cisplatin-induced hearing loss. The data is plotted as mean ± SEM (n ≥ 6). Asterisks, * p < 0.05 vs....

Case Reports: Progression of Hearing Loss Following the Completio…

WebJan 1, 2024 · The benefits of atorvastatin to the incidence of a CTCAE-defined hearing loss were generally consistent across all subgroups (Figure 3). Overall, 48.8% (156 of 320) of … WebJan 26, 2024 · But cisplatin and other similar platinum-containing drugs can damage the cochlea, leaving 40%–80% of adults, and at least 50% of children, with significant … sharm al sheikh reed fishes

Cisplatin (Intravenous Route) Side Effects - Mayo Clinic

WebOct 11, 2024 · The incidence of hearing loss in humans after aminoglycoside treatment remains unclear due to variable dose stratification regimens and limited pure-tone testing … WebApr 13, 2024 · Spankovich et al. showed a reduced cisplatin-related hearing loss by cold water irrigation in guinea pigs ( Spankovich et al., 2016 ). In an alternative rodent experiment, the otoprotective effect of hypothermia applied through a custom-made cooling device was evaluated in a cochlea implantation situation. Web顺铂治疗导致的永久性听力损失率在 40% 到 80% 之间，并且与相当大的发病率和对生活质量的负面影响有关。目前，没有 FDA 批准的预防顺铂引起的听力损失的疗法。 HMG-CoA 还原酶抑制剂（他汀类药物）由于假定的多效性作用、减少炎症和氧化应激而受到关注。一些临床前和回顾性研究表明，同时服用他汀类药物可以减少顺铂相关的听力损失。目的： … population of kenilworth warwickshire

Cells Free Full-Text Cisplatin-Induced Ototoxicity in …

Ototoxicity in Children Receiving Platinum Chemotherapy ...

WebFeb 15, 2024 · Overall, the study showed that 44% of pediatric patients treated with cisplatin suffered from moderate to severe hearing loss. But the data showed that not all treatment schedules came with the same risk. WebDec 11, 2024 · It is used for the treatment of a variety of cancers such as cervical, breast, stomach, prostate, bladder and oesophageal, to name a few. However due to its expansive toxicity profile, patients receiving cisplatin can experience high frequency hearing loss, a side effect known as ototoxicity. population of kemmerer wyWebAfter the first cycle of cisplatin, in the placebo ears, 76% of patients experienced hearing loss in the clinical frequency range that met the ototoxicity criteria established by the American Speech-Language-Hearing Association. population of kent and medway

"WebFeb 12, 2024 · Overall, the study showed that 44% of pediatric patients treated with cisplatin suffered from moderate to severe hearing loss. But the data showed that not … " - Cisplatin hearing loss data

Cisplatin hearing loss data

Atorvastatin is associated with reduced cisplatin-induced hearing …

WebThirteen percent sustained a significant hearing handicap. An interindividual variation was found, ranging from severe hearing loss after the first course to unaffected hearing after … WebFeb 11, 2024 · Cisplatin-induced hearing loss (CIHL) is a debilitating toxicity commonly experienced by patients who received cisplatin …

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WebCisplatin is one of the most effective chemotherapy agents, used in just under half of pediatric cancer cases. Permanent hearing loss is a common side effect of this … WebSigns and symptoms seen in children as ototoxicity develops include: High-frequency (≥4 kHz) sensorineural hearing loss that is bilateral (affecting both sides), progressive, and …

WebTaking a genome-wide association study approach, we identified inherited genetic variations in ACYP2 associated with cisplatin-related ototoxicity (rs1872328: P = 3.9 × 10(-8), hazard ratio = 4.5) in 238 children with newly diagnosed brain tumors, WebModern research on ototoxicity goes back to the 1940s, when streptomycin was introduced into clinical practice. Today, aminoglycoside antibiotics and platinum-based chemotherapy, mainly cisplatin, are the most important drugs that …

WebJul 13, 2024 · Hearing loss can have significant long-term consequences for children treated for cancer, said Edward Neuwelt, M.D., of Oregon Health & Science University, who helped lead both recent trials. “Around 60% to … WebAtorvastatin to Reduce Cisplatin-Induced Hearing Loss Among Individuals With Head and Neck Cancer Latest version (submitted April 11, 2024) on ClinicalTrials.gov A study version is represented by a row in the table. Select two study versions to compare. One each from columns A and B.

WebCisplatin is an effective chemotherapeutic agent against pediatric cancers; however, ototoxicity is a concern. This study describes the frequency, severity, and clinical course …

WebJan 4, 2024 · BACKGROUNDCisplatin is widely used to treat adult and pediatric cancers. It is the most ototoxic drug in clinical use, resulting in permanent hearing loss in … population of kelso scotlandWebMar 15, 2024 · Cisplatin can cause hearing loss in up to 60% of the treated population, leading to significant impact on QoL. Data from a population-based longitudinal study of age-related hearing impairment (N = 2,688) showed that 28% of adults age 53-97 years … population of kemp txWebOct 6, 2024 · Sodium thiosulfate prevents hearing loss and is safe Cisplatin belongs to a group of platinum-based chemotherapy drugs. Research has suggested that hearing loss may result from damage caused by the accumulation of cisplatin in the inner ear. population of kemptville ontario 2021WebMay 19, 2016 · He is actively involved in several human clinical trials looking at the prevention of cisplatin ototoxicity that may drastically decrease … population of kennebunk maineWebOct 6, 2024 · Cisplatin belongs to a group of platinum-based chemotherapy drugs. Research has suggested that hearing loss may result from damage caused by the … population of kemmerer wyomingWebFeb 13, 2024 · Overall, the study showed that 44% of pediatric patients treated with cisplatin suffered from moderate to severe hearing loss. But the data showed that not … population of kennebec sdWebSep 1, 2024 · Improving Ototoxicity Monitoring with Cisplatin Therapy at VA Northeast Ohio Healthcare System (VANOHS), An Interdisciplinary Team Approach. Publish date: September 1, 2024. Author(s): Lisa Arfons, MD Yasmine Ayoub, PharmD, BCPS Deborah Fox, RN, BSN, MSHS Jill Lagerstedt, MA, CCC-A, Clinical Audiologist sharma manish accenture