Human perforin
Perforin is a pore forming cytolytic protein found in the granules of cytotoxic T lymphocytes (CTLs) and natural killer cells (NK cells). Upon degranulation, perforin molecules translocate to the target cell with the help of calreticulin, which works as a chaperone protein to prevent perforin from degrading. … Meer weergeven Perforin-1 is a protein that in humans is encoded by the PRF1 gene and the Prf1 gene in mice. Meer weergeven Homozygous inheritance of defective PRF1 alleles result in the development of familial hemophagocytic lymphohistiocytosis type 2 (FHL2), a rare and lethal … Meer weergeven • Granzymes • Defensin • Complement membrane attack complex Meer weergeven • perforin at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Perforin-1 Meer weergeven Perforin has been shown to interact with calreticulin. Meer weergeven • Trapani JA (1996). "Target cell apoptosis induced by cytotoxic T cells and natural killer cells involves synergy between the pore-forming protein, perforin, and the serine … Meer weergeven Web22 jun. 2024 · Abcam’s Perforin (PRF1) Human in vitro ELISA (Enzyme-Linked Immunosorbent Assay) kit is designed for the quantitative measurement of Perforin in supernatant and buffered solutions. Note for serum & plasma quantification: high and non-linear detection level is found in Human serum and plasma samples. The high signal
Human perforin
Did you know?
WebPerforin: structure, function, and role in human immunopathology. The secretory granule-mediated cell death pathway is the key mechanism for elimination of virus-infected and … WebPerforin is a 70 kD cytolytic protein that is expressed in the cytoplasmic granules of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. Perforin is one of the major …
WebPerforin and granzymes: function, dysfunction and human pathology A defining property of cytotoxic lymphocytes is their expression and regulated secretion of potent toxins, … WebDescription Perforin is a 70 kD cytolytic protein that is expressed in the cytoplasmic granules of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. Perforin is one of the major effector molecules used by cytotoxic T cells and NK cells to mediate targeted cell lysis. Product Details Technical Data Sheet (pdf) Product Details
Web1 nov. 2004 · Cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells use the perforin/granzyme pathway as a major mechanism to kill pathogen-containing cells and tumor cells. 1, 2 Dysregulation of this pathway results in several human diseases, such as hemophagocytic lymphohistiocytosis. WebARG80173 Human Perforin ELISA Kit is an Enzyme Immunoassay kit for the quantification of Human Perforin in Serum, Plasma, Cell culture supernatants. Tested Reactivity. Hu. Tested Application. ELISA. Specificity. No significant cross-reactivity or interference with Human IL-1 beta, IL-2, IL-3, IFN- gamma, TNF alpha, Fas, Fas-L, TRAIL. Target Name.
WebRecognizes natural human Perforin Incubation 2h45 Sample Type Supernatant, Buffered Solutions, Not suitable for use with serum and plasma. Sample Size 100 µl Cross Reaction No cross reactivity with Trail, TRAIL R3, TRAIL R4, Granzyme B, TNFα, IFNγ, Fas, Fas L, IL-1b, IL-2 Kit Content
WebView Human Perforin Antibody (MAB103853-100) datasheet. Detection of Perforin in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) were stained with (A) Mouse Anti-Human Perforin Monoclonal Antibody (Catalog # MAB103853) or (B) isotype control antibody followed by Anti-Mouse IgG Allophycocyanin … radiosveglia majesticWeb29 mrt. 2024 · Title: Human intestinal and circulating invariant natural killer T cells are cytotoxic against colorectal cancer cells via the perforin-granzyme pathway. Spectrum mutations of PRF1, UNC13D, STX11, and STXBP2 genes in Vietnamese patients with hemophagocytic lymphohistiocytosis. Title: Spectrum mutations of PRF1, UNC13D, … radio suzuki swift 2006WebDescription Perforin is a 70 kD cytolytic protein that is expressed in the cytoplasmic granules of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. Perforin is one of the major effector molecules used by cytotoxic T cells and NK cells to mediate targeted cell lysis. Product Details Technical data sheet Product Details Isotype Control drainage nach kreuzband opWebDescription Perforin is a 70 kD cytolytic protein that is expressed in the cytoplasmic granules of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. Perforin is one of the major effector molecules used by cytotoxic T cells and NK cells to mediate targeted cell lysis. Product Details Technical data sheet Product Details Isotype Control drainage obiWeb28 aug. 2012 · Abcam’s Perforin (PRF1) Human in vitro ELISA (Enzyme-Linked Immunosorbent Assay) kit is designed for the quantitative measurement of Perforin in supernatant and buffered solutions. A … radio suzuki swift 2011Web27 mrt. 2024 · ELISA Flex: Human Perforin (HRP) Application: ELISA: Analyte: Perforin: Reactivity: Human, Non-human primates: Specificity: This kit is based on a matched … radio suzuki sx4 2011WebPerforin is a 70 kD cytolytic protein that is expressed in the cytoplasmic granules of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. Perforin is one of the major … drainage nach brustkrebs op