Klf6 inhibitor

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August undefined, 2024

WebRecently, Klf6 super-enhancer which strongly regulates Klf6 gene expression has been identified, and the function of Klf6 super-enhancer which regulates cell growth was … WebBackground: Krüppel-like factor 6 (KLF6) is a transcription factor that participate in various pathophysiological processes, but its contribution in ischemia acute kidney injury (AKI) is …

KLF2 - an overview ScienceDirect Topics

WebSep 14, 2006 · Furthermore, KLF6 inhibited cell proliferation partly through transactivating p21WAF1, which encodes a cyclin-dependent kinase inhibitor of the cell cycle in a p53-independent pathway (Narla et al., 2001). So KLF6 may play a role in cancer pathogenesis. However, the relation of KLF6 with HCCs is little known. WebNov 25, 2010 · Indeed, KLFs have been implicated in subtypes of leukemia, lymphoma, autoimmunity, and in acute and chronic inflammatory disease states, such as atherosclerosis, diabetes, and airway inflammation, raising the possibility that KLFs and their upstream signals are of therapeutic interest. oregon snap ea

(PDF) The disruption of Klf6-related super-enhancer induces …

WebMar 2, 2024 · The KLF6 gene, which belongs to the Krüppel-like family of C2H2 zinc finger TFs, is closely related to the formation, development, and metastasis of tumors in the malignant tumors, including prostate, colon, stomach, liver, lung, neck, pituitary and nervous system [ 15, 16 ]. WebDec 19, 2013 · KLF6 is ubiquitously expressed in human tissues and regulates many pathways such as differentiation, development, cellular proliferation, growth-related signal transduction, and apoptosis. ... KLF6 mRNA decreased within 45 min to 4 h in the presence of the transcription inhibitor actinomycin D and was reduced by 95% after 4 h of … WebFeb 3, 2016 · Myeloid KLF6 is upregulated in human and experimental IBD. Our previous work demonstrated that KLF6 is the most highly expressed Kruppel-like transcription factor in macrophages and contributes to ... how to unstop a tub drain with shop vac

Krüppel-Like Factor 6 Splice Variant 1: An Oncogenic Transcription …

A new role for the Kruppel-like transcription factor KLF6 as an ...

WebDec 21, 2001 · Induction of KLF6 resulted in a fivefold increase in the expression of p21 (WAF1/CIP1), an inhibitor of several cyclin-dependent kinases and a key regulator of the G 1 /S transition , and a reduction in proliferating cell nuclear antigen (PCNA) expression (Fig. 3B) . Web目的:检测诱导型一氧化氮合酶(inducible nitric oxide synthase,iNOS)在胃癌前病变及胃癌的表达,及其与幽门螺杆菌(Helicobacter pylori,Hp)感染的相关性,探讨Hp感染与胃癌发生的关系.方法:收集慢性浅表性胃炎(chronic superficial gastritis,CSG),慢性萎缩性胃炎伴肠上皮化生(Intestinal metapla oregon snap policy manualWebApr 2, 2013 · KLF6 is a member of the Krüppel-like Factors (KLF) gene family which are a group of transcription factors that contain three highly conserved Cys 2 -His 2 type zinc fingers located in the C-terminus [ 1, 2 ]. Subsequently, these proteins regulate a vast range of target genes by preferentially binding to cognate GC-boxes or CACCC elements. how to unstop a severely clogged toilet

"WebBackground: Macrophage polarization regulates human inflammatory disorders.Results: KLF6 is a novel transcriptional regulator of macrophage polarization.Conclusion: KLF6 regulates macrophage inflammatory gene expression by modulating functions of NF-κB and PPARγ.Significance: Pharmacological agents that modulate KLF6 signaling may allow for … " - Klf6 inhibitor

Klf6 inhibitor

Circular RNA circ-ABCB10 Promotes Proliferation and Inhibits ... - Hindawi

Web(A) KLF5 and KLF6 mRNA expression in NB4 and NB4-R2 cells during ATRA-induced neutrophil differentiation. KLF5 and KLF6 mRNA levels were determined by RQ-PCR in control and ATRA-treated NB4 and... WebApr 27, 2024 · KLF6 is a direct target of miR-24. a 3’UTR of KLF6 was highly conserved to bind with miR-24. b miR-24 mimic could repress the fluorescence in KLF6 wild type. c KLF6 expression was increased markedly in cardiac fibroblasts treated with LPS. d miR-24 mimic remarkably inhibited KLF6 expression. e KLF6 mimic could relieve the inhibition of PVT1 …

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WebAdenomatous polyposis coli (APC) also known as deleted in polyposis 2.5 (DP2.5) is a protein that in humans is encoded by the APC gene. The APC protein is a negative regulator that controls beta-catenin concentrations and interacts with E-cadherin, which are involved in cell adhesion.Mutations in the APC gene may result in colorectal cancer.. APC is … WebOct 28, 2004 · Our data are consistent with a novel mechanism of KLF6's role as an inhibitor of cell proliferation by counteracting the function of the c-Jun proto-oncoprotein involving …

WebFeb 26, 2024 · However, KLF6 was identified as a tumor suppressor to inhibit glioblastoma by several research groups [34, 35]. Collectively, KLF6 may exert both anti-tumorigenic … This gene encodes a nuclear protein that has three zinc fingers at the end of its C-terminal domain, a serine/threonine-rich central region, and an acidic domain lying within the N-terminal region. The zinc fingers of this protein are responsible for the specific DNA binding with the guanine-rich core promoter elements. The central region might be involved in activation or posttranslational regulatory pathways, and the acidic N-terminal domain might play an importan…

WebMar 31, 2024 · KLF6 and SP2-shaped SP2/KLF6 inhibitor complex are closely related to the regulation of cell movement. Other studies have indicated that KLF6 and SP2 can bind to the promoter of matrix metalloproteinase 9 and keep the gene in the gene sink together. The silent state reduces the level of protein, which affects the migration of cells. WebMay 27, 2024 · For miR-181d-5p overexpression and inhibition, we used AAV vectors in mice and a miR-181d-5p mimic and inhibitor in HK-2 cells. Experimentally, KLF6 expression was significantly decreased after miR-181d-5p upregulation but increased after miR-181d-5p downregulation in the model of renal ischemia for 45 min/reperfusion for 24 h (Figures …

Webc-Jun jest protein koji je kod ljudi kodiran genom JUN sa hromosoma 1. c-Jun, u kombinaciji sa c-Fos, formira AP-1 transkripcijski faktor za rani odgovor, Prvo je identificiran kao Fos-vezujući protein p39 i tek kasnije ponovo otkriven kao proizvod gena JUN. c-jun je bio prvootkriveni onkogeni transkripcijski faktor. The proto-oncogene c-Jun je ćelijski …

WebAug 9, 2024 · KLF6 binds to different acetyl-transferases, including cyclic adenosine monophosphate response element-binding protein ( CREBBP ), p300, and p300/CBP-associated factor [ 32 ]. The binding of KLF6 to these … how to unstop a kitchen garbage disposalWebKrueppel-like factor 6 is a protein that in humans is encoded by the KLF6 gene. [5] It is a tumor suppressor gene. [6] Function [ edit] This gene encodes a nuclear protein that has three zinc fingers at the end of its C-terminal domain, a serine/threonine-rich central region, and an acidic domain lying within the N-terminal region. how to unstop a washing machine drainWebJul 1, 2005 · KLF6 is a member of the Kruppel-like family of zinc finger transcription factors which are DNA-binding proteins regulating growth-related signal transduction pathways, … oregons newest casinoWebFeb 26, 2024 · Ectopic expression of KLF6 or disruption of CBX4-HDAC1 interaction attenuates CBX4-mediated cell growth and migration. Furthermore, CBX4 depletion markedly enhances the histone deacetylase inhibitor (HDACi)-induced cell apoptosis and suppression of tumor growth. Interpretation Our data suggest CBX4 as an oncogene with prognostic … how to unstop drain in sinkWebApr 4, 2024 · Hotspot mutant p53-R273H inhibits KLF6 expression to promote cell migration and tumor metastasis. KLF6 Induces Apoptosis in Human Lens Epithelial Cells Through … how to unstop a tub drainWebSep 1, 2024 · Inhibition of KLF6 promoted the viability and reduced the inflammation and apoptosis of LPS-induced A549 cells, which was reversed by CYR61. Inhibition of KLF6 … oregons new car taxWebNational Center for Biotechnology Information oregon snap program school ebt