Macc1 inhibitor

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August undefined, 2024

WebSep 16, 2011 · Background Metastasis-associated in colon cancer 1 (MACC1) is demonstrated to be up-regulated in several types of cancer, and can serve as biomarker for cancer invasion and metastasis. To investigate the relations between MACC1 and biological processes of ovarian cancer, MACC1 specific small hairpin RNA (shRNA) expression … WebThe newly identified MEK1 tyrosine phosphorylation target MACC1 is druggable by approved MEK1 inhibitors to restrict colorectal cancer metastasis. Oncogene , 40 (34), 5286 …

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WebFeb 1, 2024 · By performing human MACC1 promoter-based high throughput screens (HTS), we identified FDA-approved small molecule drugs such as lovastatin and rottlerin as transcriptional inhibitors of MACC1. These compounds impaired the binding of the transcription factors c-Jun/AP1 to the human MACC1 promoter, which resulted in … WebJun 1, 2024 · Abstract. MACC1 (Metastasis Associated in Colon Cancer 1) is a key driver and prognostic biomarker for cancer progression and metastasis in a large variety of … most reliable keyless door locks

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WebFeb 28, 2024 · Now together with Dr. Robert Preißner of Charité, Stein has discovered what could disrupt metastatic progression in such cases: Statins, which are prescribed as … WebApr 2, 2009 · In addition, MACC1 inhibitors may be developed to disrupt aberrant signaling of HGF/MET, thus minimizing tumor invasion and metastasis and providing benefits to … WebJan 14, 2024 · The MACC1 rs975263 polymorphisms is associated with aberrant AST/ALT ratio before adjusted with age and alcohol drinking, and may have a potential synergistic … most reliable kia sportage year

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WebAug 6, 2024 · To investigate whether MACC1 expression is regulated by Wnt/β-catenin signaling pathway, we treated colon cancer cells (SW480 and HT-29) with either LiCl, a GSK3β inhibitor, or Wnt3a-conditioned ... WebSep 5, 2024 · MACC1- WT and MACC1-Mut were generated in the same way. Cells were co-transfected with indicated vectors and miR-3163 mimic or negative control NC mimic via utilization of Lipofectamine 2000 (Invitrogen) following the product instructions. The luciferase activity was tested with Dual-Luciferase Reporter Assay System (Promega). minimalist watches m1WebOct 4, 2024 · MACC1 promotes carcinogenesis, growth and metastasis of colorectal cancer (6,7). Furthermore, ... Ser473; cat. no. 11054-1) were purchased from Signalway Antibody LLC (College Park, MD, USA). The PI3K inhibitor LY294002 was purchased from Selleck Chemicals (Houston, TX, USA). Cells were treated with LY294002 (20 µM) for 2 h at 37°C. minimalist watches india

"WebApr 12, 2024 · Anlotinib is a newly approved orally administrative small-molecule receptor tyrosine kinases (RTK) inhibitor that targets to RTKs related to tumor proliferation and metastasis, ... In contrast, inhibition of miR-940 by transfection of miR-940’s inhibitor or MACC1 with a mutated miR-940 binding site (MACC1 Mut) blocked the effect of miR-940 … " - Macc1 inhibitor

Macc1 inhibitor

Long non-coding FAM201A accelerates the tumorigenesis and …

WebApr 25, 2012 · Metastasis-associated in colon cancer-1 (MACC1) has been newly identified to express highly in colorectal cancer (CRC) and promote tumor metastasis through …

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WebFeb 28, 2024 · Now together with Dr. Robert Preißner of Charité, Stein has discovered what could disrupt metastatic progression in such cases: Statins, which are prescribed as cholesterol -lowering drugs, inhibit... WebWe generated the first transgenic MACC1 mouse models, discovering MACC1-induced cancer transition and its link to stemness. We identified the first transcriptional and post-translational small molecule inhibitors, restricting MACC1-induced metastasis formation in …

WebMay 10, 2015 · MACC1 enhanced TWIST1/2 promoter activity and facilitated VM, while silencing of TWIST1 or TWIST2 inhibited VM. Hepatocyte growth factor (HGF) increased the nuclear translocation of MACC1, TWIST1, and TWIST2, while a … WebAdditionally, MACC1 overexpression has been reported to induce the growth of several types of cancers, including glioblastoma multiforme and gastric cancer. However, whether MACC1 also plays a role in the progression of osteosarcoma remains unclear. ... The current priority is to develop MACC1 inhibitors to test their potential antitumor ...

WebSep 5, 2024 · FAM201A regulates the expression of MACC1 via a miRNA-dependent mechanism. (A) The putative miR-3163 binding sites in the 3′UTR of MACC1. (B) The expression pattern of MACC1 was evaluated by RT-qPCR assay. (C) Luciferase reporter assay validated the interplay of miR-3163 with MACC1. WebSep 30, 2008 · Abstract. Receptor tyrosine kinases are often aberrantly activated in human malignancies and contribute to cancer development and progression. Specific receptor tyrosine kinase inhibitors have been shown to be clinically effective therapies in subsets of cancer patients with either hematologic or solid tumors. Activation of the hepatocyte …

WebMACC1 represents an early and crucial prognostic indicator for colon cancer metastasis that is independent of age, sex, tumor infiltration, nodal status, and lymph vessel invasion. …

WebJun 1, 2024 · MACC1 (Metastasis Associated in Colon Cancer 1) is a key driver and prognostic biomarker for cancer progression and metastasis in a large variety of solid … most reliable kia soul yearsWebDownload scientific diagram DLC3 suppressed GC growth and metastasis in athymic mouse. (A to D) MKN45 cell xenograft were transplanted subcutaneously. (A) Representative image of mouse at Day 34. most reliable kitchenaid dishwasherWeb一站式科研服务平台. 学术工具. 文档翻译; 收录引证; 论文查重; 文档转换 most reliable kitchen appliances 2013WebLong Intergenic Non-Coding RNA LINC00885 Promotes Tumorigenesis of Cervical Cancer by Upregulating MACC1 Expression Through Serving as a Competitive Endogenous RNA for microRNA-432-5p Javascript is currently disabled in your browser. most reliable kitchen appliance brand 2022WebNov 4, 2024 · Nevertheless, the inhibitor failed to reverse MACC1-mediated cell migration and invasion (Fig. 2O, P and Fig. S3G, H). These results indicated that MACC1 enhances PC cell migration and invasion in ... most reliable kitchen appliances 2016WebMar 31, 2024 · MACC1 gene expression is correlated with survival and morphological characteristics. In vitro analysis of lentivirally MACC1-manipulated subclones of FLO-1 … most reliable kitchen appliances 2014WebJun 1, 2024 · MACC1 is a known driver for cancer metastasis and a prominent modulator of drug response in CRC [23,24, 26]. It acts as a transcription factor regulating genes involved in EMT, such as c-MET... most reliable kitchen appliance brand 2021