Proteome-wide mendelian randomization
Webb11 apr. 2024 · To that end, we integrated AD GWAS results with human brain proteomes to perform a proteome-wide association study (PWAS) of AD, followed by Mendelian randomization and colocalization analysis. Webb6 juli 2024 · Mendelian Randomization (MR) in this context uses genetic variants to estimate the effect of an exposure on an outcome, using the randomness by which alleles are allocated to gametes to remove the effects of unmeasured confounding between a protein and the outcome [ 9 ].
Proteome-wide mendelian randomization
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Webb期刊：Gastroenterology文献作者：Jérome Bourgault; Erik Abner; Hasanga D. Manikpurage; Natàlia Pujol-Gualdo; Triin Laisk; Emilie Gobeil; Eloi Gagnon; Arnau ... Webb1 jan. 2024 · A large-scale plasma proteome Mendelian randomization study identifies novel causal plasma proteins related to primary biliary cholangitis. Yang H , Chen L , Liu Y. Front Immunol, 14:1052616, 07 Feb 2024. Cited by: 0 articles PMID: 36825008 …
Webb31 jan. 2024 · Since obesity influences the plasma proteome, we sought to identify circulating proteins mediating the effects of obesity on COVID-19 severity in humans. Here, we screened 4,907 plasma proteins to identify proteins influenced by body mass index (BMI) using Mendelian randomization (MR). Webb1 feb. 2024 · Proteome-Wide Mendelian Randomization Studies of Acute Pancreatitis. We investigated the associations of 4907 and 4979 plasma protein levels with AP using …
Webb11 apr. 2024 · Herein, we performed a two-sample Mendelian randomization (MR) analysis to investigate the associations of genetically determined plasma ICAM-4 with the risks of ischemic stroke and its subtypes. A total of 11 single-nucleotide polymorphisms associated with ICAM-4 were selected as instrumental variables based on the genome … Webb17 okt. 2024 · Mendelian randomization supports atrial fibrillation, body mass index, smoking, blood pressure, white matter hyperintensities and type 2 diabetes as stroke risk …
Webb27 feb. 2024 · We conducted a proteome-wide Mendelian randomization (MR) and colocalization analyses to identify possible targets for IBD. Methods Summary-level data …
Webb3 mars 2024 · Using genetic instruments and under the assumptions of Mendelian randomization, our proteome-wide analyses are consistent with higher levels of certain blood proteins being causally associated with risk of being hospitalized due to COVID-19, and subsequently experiencing the most severe form including respiratory support or … sacheen littlefeather nowWebb13 dec. 2024 · Proteome-wide and transcriptome-wide associations were determined by functional summary-based imputation leveraging data from genome-wide association summary (56 306 Europeans, 1.4 million controls), brain proteomes (528 cases from 2 separate data sets), and transcriptome (452 cases), followed by Mendelian … sacheen littlefeather novatoWebb9 mars 2024 · Proteome-wide Mendelian randomization identifies causal links between blood proteins and severe COVID-19 Alish B. Palmos1,2*†, Vincent Millischer3,4†, DavidK.Menon5, Timothy R. Nicholson2,10, Leonie Taams6, Benedict Michael8, COVID Clinical NeuroscienceStudy Consortium, Christopher Hübel1,2,9‡and Gerome Breen1,2‡ … sacheen littlefeather new york timesWebb3 mars 2024 · In November 2024, the COVID-19 pandemic death toll surpassed five million individuals. We applied Mendelian randomization including >3,000 blood proteins as … is homer simpson a humanWebb12 dec. 2024 · Integration of large-scale protein-level genome-wide association studies (GWAS) and disease-related GWAS has thus connected genetic variation to disease … sacheen littlefeather lied about john wayneWebb28 feb. 2024 · The proteome is a major source of therapeutic targets. We conducted a proteome-wide Mendelian randomization (MR) and colocalization analyses to identify possible targets for IBD. sacheen littlefeather john wayne yoWebb14 nov. 2024 · Colocalization, gene expression profiling, and Mendelian randomization provide convergent evidence for the roles of BCKDHA and circulating branch-chain amino acids in heart failure and cardiac structure. Finally, proteome-wide Mendelian randomization identifies 9 circulating proteins associated with heart failure or … is homer remote